The effect of mutation in the gene of cationic trypsinogen PRSS1 on the severity of acute pancreatitis
Reply. We have read the comments on our article by Witt et al. and Chen et al. with great interest. It is especially worth notin
Mouse Models of Trypsin-Dependent Pancreatitis I. Mouse Models with Increased Trypsinogen Autoactivation
![PRSS1 mutation: a possible pathomechanism of pancreatic carcinogenesis and pancreatic cancer | Molecular Medicine | Full Text PRSS1 mutation: a possible pathomechanism of pancreatic carcinogenesis and pancreatic cancer | Molecular Medicine | Full Text](https://media.springernature.com/lw685/springer-static/image/art%3A10.1186%2Fs10020-019-0111-4/MediaObjects/10020_2019_111_Fig5_HTML.png)
PRSS1 mutation: a possible pathomechanism of pancreatic carcinogenesis and pancreatic cancer | Molecular Medicine | Full Text
![Enrique de-Madaria on Twitter: "@my_ueg @AESPANC @aecirujanos @hpb_so @me4_so @JeanDonet @AustinChiangMD @AGA_Gastro @nature Mutations in the gene encoding the pancreatic enzyme carboxypeptidase A1 (CPA1) cause protein misfolding resulting in impaired ... Enrique de-Madaria on Twitter: "@my_ueg @AESPANC @aecirujanos @hpb_so @me4_so @JeanDonet @AustinChiangMD @AGA_Gastro @nature Mutations in the gene encoding the pancreatic enzyme carboxypeptidase A1 (CPA1) cause protein misfolding resulting in impaired ...](https://pbs.twimg.com/media/ED7OehAWwAQ23b2.png)
Enrique de-Madaria on Twitter: "@my_ueg @AESPANC @aecirujanos @hpb_so @me4_so @JeanDonet @AustinChiangMD @AGA_Gastro @nature Mutations in the gene encoding the pancreatic enzyme carboxypeptidase A1 (CPA1) cause protein misfolding resulting in impaired ...
![Gene Conversion Between Cationic Trypsinogen (PRSS1) and the Pseudogene Trypsinogen 6 (PRSS3P2) in Patients with Chronic Pancreatitis - Rygiel - 2015 - Human Mutation - Wiley Online Library Gene Conversion Between Cationic Trypsinogen (PRSS1) and the Pseudogene Trypsinogen 6 (PRSS3P2) in Patients with Chronic Pancreatitis - Rygiel - 2015 - Human Mutation - Wiley Online Library](https://onlinelibrary.wiley.com/cms/asset/c87de07c-20e3-48bc-a47c-cbd58e20ceee/humu22747-fig-0001-m.jpg)
Gene Conversion Between Cationic Trypsinogen (PRSS1) and the Pseudogene Trypsinogen 6 (PRSS3P2) in Patients with Chronic Pancreatitis - Rygiel - 2015 - Human Mutation - Wiley Online Library
![SPINK1 mutation in a pediatric patient with chronic pancreatitis: A case report | Revista de Gastroenterología de México SPINK1 mutation in a pediatric patient with chronic pancreatitis: A case report | Revista de Gastroenterología de México](https://multimedia.elsevier.es/PublicationsMultimediaV1/item/multimedia/thumbnail/S2255534X15000390:gr2.jpeg?xkr=ue/ImdikoIMrsJoerZ+w97o/wdEXW47bqlyT1CqG6R0=)
SPINK1 mutation in a pediatric patient with chronic pancreatitis: A case report | Revista de Gastroenterología de México
Increased Activation of Hereditary Pancreatitis-associated Human Cationic Trypsinogen Mutants in Presence of Chymotrypsin C*
![A preclinical model of chronic pancreatitis driven by trypsinogen autoactivation | Nature Communications A preclinical model of chronic pancreatitis driven by trypsinogen autoactivation | Nature Communications](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41467-018-07347-y/MediaObjects/41467_2018_7347_Fig1_HTML.png)
A preclinical model of chronic pancreatitis driven by trypsinogen autoactivation | Nature Communications
![PDF] Mutations in the cationic trypsinogen gene are associated with recurrent acute and chronic pancreatitis by Michael C. Gorry, D Gabbaizedeh, William Furey, Gates Lk, Preston Ra, Christopher E. Aston, Yingze Zhang, PDF] Mutations in the cationic trypsinogen gene are associated with recurrent acute and chronic pancreatitis by Michael C. Gorry, D Gabbaizedeh, William Furey, Gates Lk, Preston Ra, Christopher E. Aston, Yingze Zhang,](https://og.oa.mg/Mutations%20in%20the%20cationic%20trypsinogen%20gene%20are%20associated%20with%20recurrent%20acute%20and%20chronic%20pancreatitis.png?author=%20Michael%20C.%20Gorry,%20D%20Gabbaizedeh,%20William%20Furey,%20Gates%20Lk,%20Preston%20Ra,%20Christopher%20E.%20Aston,%20Yingze%20Zhang,%20C%20Ulrich,%20Garth%20D.%20Ehrlich,%20David%20C.%20Whitcomb)
PDF] Mutations in the cationic trypsinogen gene are associated with recurrent acute and chronic pancreatitis by Michael C. Gorry, D Gabbaizedeh, William Furey, Gates Lk, Preston Ra, Christopher E. Aston, Yingze Zhang,
![Figure 1 from Human cationic trypsinogen (PRSS1) variants and chronic pancreatitis. | Semantic Scholar Figure 1 from Human cationic trypsinogen (PRSS1) variants and chronic pancreatitis. | Semantic Scholar](https://d3i71xaburhd42.cloudfront.net/21b9b7c0fec2380d35e5d233a2ba746392e44130/3-Figure1-1.png)
Figure 1 from Human cationic trypsinogen (PRSS1) variants and chronic pancreatitis. | Semantic Scholar
![PDF] R116C Mutation of Cationic Trypsinogen in a Turkish Family with Recurrent Pancreatitis Illustrates Genetic Microheterogeneity of Hereditary Pancreatitis | Semantic Scholar PDF] R116C Mutation of Cationic Trypsinogen in a Turkish Family with Recurrent Pancreatitis Illustrates Genetic Microheterogeneity of Hereditary Pancreatitis | Semantic Scholar](https://d3i71xaburhd42.cloudfront.net/c5c400089d4079d9599ac28481dee181f837f4e3/4-Figure2-1.png)
PDF] R116C Mutation of Cationic Trypsinogen in a Turkish Family with Recurrent Pancreatitis Illustrates Genetic Microheterogeneity of Hereditary Pancreatitis | Semantic Scholar
![Tighter Control by Chymotrypsin C (CTRC) Explains Lack of Association between Human Anionic Trypsinogen and Hereditary Pancreatitis*♢ - Journal of Biological Chemistry Tighter Control by Chymotrypsin C (CTRC) Explains Lack of Association between Human Anionic Trypsinogen and Hereditary Pancreatitis*♢ - Journal of Biological Chemistry](https://www.jbc.org/cms/asset/3af1c926-dd4e-427a-bef9-7e3ae597dab1/gr1.jpg)
Tighter Control by Chymotrypsin C (CTRC) Explains Lack of Association between Human Anionic Trypsinogen and Hereditary Pancreatitis*♢ - Journal of Biological Chemistry
![JCI - Trypsin activity governs increased susceptibility to pancreatitis in mice expressing human PRSS1R122H JCI - Trypsin activity governs increased susceptibility to pancreatitis in mice expressing human PRSS1R122H](https://dm5migu4zj3pb.cloudfront.net/manuscripts/130000/130172/medium/JCI130172.ga.jpg)
JCI - Trypsin activity governs increased susceptibility to pancreatitis in mice expressing human PRSS1R122H
![Schematic mechanism underlying mutations associated with pancreatitis.... | Download Scientific Diagram Schematic mechanism underlying mutations associated with pancreatitis.... | Download Scientific Diagram](https://www.researchgate.net/publication/282037393/figure/fig3/AS:281927367053317@1444228130922/Schematic-mechanism-underlying-mutations-associated-with-pancreatitis-The-PRSS1-mutation.png)
Schematic mechanism underlying mutations associated with pancreatitis.... | Download Scientific Diagram
![Genes | Free Full-Text | Genetic Risk Factors in Early-Onset Nonalcoholic Chronic Pancreatitis: An Update Genes | Free Full-Text | Genetic Risk Factors in Early-Onset Nonalcoholic Chronic Pancreatitis: An Update](https://www.mdpi.com/genes/genes-12-00785/article_deploy/html/images/genes-12-00785-g001.png)
Genes | Free Full-Text | Genetic Risk Factors in Early-Onset Nonalcoholic Chronic Pancreatitis: An Update
![A Thai family with hereditary pancreatitis and increased cancer risk due to a mutation in PRSS1 gene A Thai family with hereditary pancreatitis and increased cancer risk due to a mutation in PRSS1 gene](https://f6publishing.blob.core.windows.net/a488260d-8048-4cd6-961f-02b96800eedf/WJG-11-1634-g003.jpg)
A Thai family with hereditary pancreatitis and increased cancer risk due to a mutation in PRSS1 gene
![PDF) Mutations in the pancreatic secretory trypsin inhibitor gene (PSTI/SPINK1) rather than the cationic trypsinogen gene (PRSS1) are significantly associated with tropical calcific pancreatitis | idris muhammad - Academia.edu PDF) Mutations in the pancreatic secretory trypsin inhibitor gene (PSTI/SPINK1) rather than the cationic trypsinogen gene (PRSS1) are significantly associated with tropical calcific pancreatitis | idris muhammad - Academia.edu](https://0.academia-photos.com/attachment_thumbnails/47851023/mini_magick20190205-12862-3hspve.png?1549408975)